Esulin Special Functions

1) How do the actives formula work in our body? The mechanism.

When tested on diabetes mice, Esulin proven to be able to reduce the mice blood glucose level, reduce Hemoglobin A1c (HbA1c) level, improve blood glucose usage and blood triglycerides profile. When observed Through telescope, it's prominently display that Esulin able to improve pancreas related disease, thus increase the quantity of Beta cells. It blood glucose reduce effect is similar to synthetic medicines - Thiazolidinediones (TZDs).

At the same time, Esulin can increase quantity of insulin been used in diabetes mice, thus improve body cells sensitivity to insulin, and result in reduce " insulin resistance". It's also increase 4main basic how the transportation of blood glucose into cells, thus increase insulin been used in body through Esulin, and improve cells sensitivity to insulin. This is one of the mechanism how Esulin been used to treat Diabetes type 2 patients, however the detail mechanism that make Esulin so effective have yet be established and confirm and need further research.

Through clinical trials, it is show that Esulin able to stimulate the cells sensitivity to insulin, increase blood glucose usage by cells thus reduce blood sugar level. This clearly reduce the blood sugar level before food, insulin and C level, blood sugar level after food and insulin showed sight of reduce and the level of HbA1c also reduce prominently.

2) How Esulin work to reduce the HbA1c level ?

• Esulin decrease insulin resistance by enhancing the effects of insulin, its sensitize the body’s tissues to insulin. To understand how it’s work, first we have to understand how HbA1c is formed. THE KEY WORD IS “THE LENGTH OF TIME THAT THE HAEMOGLOBIN IS EXPOSED TO A GIVEN CONCENTRATION OF GLUCOSE"

• The longer the blood glucose level is high, the more glycosylation ( a process where HbA1c is formed when glucose molecules attach to HbA molecules) will occur. This factor is influenced by the age of the red blood cell – many cells in our body are continually being broken down and replaced; the average life span of a red blood cell is about 120 days.

• The hemoglobin is continuously being glycated at a rate which is proportional to the prevailing blood glucose level. At any given time, there will be a mixture of old and new red blood cells circulating in the bloodstream. Old cells will have been exposed to recent, and not so recent, blood glucose levels. New cells will only have been exposed to recent blood glucose levels. So the more recent glycaemia will have the largest influence on the overall HbA1c reading. Indeed, it has been suggested that half of an HbA1c value is attributable to the previous month, a further quarter to the month before that, and the remaining quarter to the two months before that.

• By controlling the concentration of glucose level by Esulin, its control the most recent glycaemia or half Of the (50%) HbA1c value attributed by the previous month. Esulin increases insulin sensitivity, by increasing insulin action, it increases glucose utilization. But the effects are not instantaneous, it may be up to a week or two before a significant improvement in blood glucose levels can be seen. Esulin also decreases “hepatic glucose production” (HGP), which is glucose released into the bloodstream by the liver. (The liver normally tops up the blood glucose during fasting and especially overnight. Insulin resistance at the liver can result in an increased output of glucose).

• In addition to its blood glucose lowering effects, Esulin also has beneficial effects on blood lipid profiles.